Obgist | Nigeria News, Celebrity Scoop, International Gist and Tech News

A quick look at the 49 U.S. AI startups that crossed $100M in funding this year, marking another explosive phase in AI growth.

Last year was huge for artificial intelligence across the U.S. tech scene.

But 2025 is proving to be just as fiery if not hotter.

In 2024, TechCrunch counted 49 startups that pulled in funding rounds of $100 million and above. A handful even secured billion-dollar rounds more than once.

Now, as 2025 races toward its final month, the momentum hasn’t slowed. The number of U.S. AI companies raising $100 million or more has already matched last year with even more startups recording multiple mega-rounds within the same year.

Below is a clean breakdown of every U.S. AI startup that crossed the $100 million mark in 2025 starting with the most recent.

November: Big money, back-to-back rounds

Anysphere, creators of the viral coding tool Cursor, shocked the market with a massive $2.3 billion round on November 13, pushing its valuation to $29.3 billion — its second mega-raise this year.

Parallel, a company building web infrastructure for AI agents, secured a $100 million Series A on November 12, co-led by Index Ventures and Kleiner Perkins.

Healthcare-focused Hippocratic AI also returned for a second raise this year, announcing a $126 million Series C on November 3, valuing the startup at $3.5 billion.

October: Billion-dollar valuations everywhere

Fireworks AI grabbed headlines with a $250 million Series C on October 28, valuing it at $4 billion.

Enterprise AI firm Uniphore followed, landing $260 million and jumping to a $2.5 billion valuation.

Voice AI startup Sesame raised $250 million in a round co-led by Sequoia and Spark Capital.

Medical AI platform OpenEvidence posted its second raise of the year a $200 million Series C pushing the company’s valuation to $6 billion.

Science-focused Lila Sciences secured $350 million on October 14, while Reflection AI raised a stunning $2 billion Series B led by Nvidia.

Legal-tech AI company EvenUp closed October with a $150 million Series E, now valued above $2 billion.

September: Infrastructure and multimodal giants dominate

Periodic Labs set a new bar for seed funding, raising $300 million to build an AI scientist.

AI chipmaker Cerebras Systems secured $1.1 billion, valuing it at $8.1 billion.

Modular, Distyl AI, and Upscale AI all crossed the $100 million mark, while inference company Groq pulled in $750 million, bringing its valuation near $6.9 billion.

AI training firm Invisible Technologies hit a $2 billion valuation after a $100 million round.

Cognition AI, creators of Devin, raised $400 million, while infrastructure startup Baseten closed $150 million.

Bret Taylor’s AI agent platform Sierra landed $350 million, valuing the company above $10 billion.

Search engine You.com secured $100 million, and AI giant Anthropic raised an eye-watering $13 billion, taking its valuation to $183 billion.

August: Healthtech stays hot

Healthcare automation startup EliseAI raised $250 million, valuing it at $2.2 billion.

Research lab Decart followed with a $100 million raise at $3.1 billion valuation.

July: Media and research labs grab big rounds

Generative media platform Fal raised $125 million, while healthcare OS startup Ambience Healthcare secured $243 million.

AI lab Reka AI added $110 million, and hyperscaling lab Thinking Machines stunned the market with a $2 billion seed round.

OpenEvidence and reasoning engine Harmonic also secured major funding rounds.

June: Billion-dollar valuations keep coming

Healthcare unicorn Abridge raised $300 million.

Legal-tech giant Harvey pulled another $300 million, bringing its valuation to $5 billion.

Tennr, Glean, and Anysphere each hit new funding milestones, with Glean’s Series F valuing it at $7.25 billion.

May: Infrastructure and benchmarking tools shine

Snorkel AI, LMArena, and TensorWave all hit the $100 million range, with strong participation from major VC powerhouses.

April: Quantum and media AI rise

SandboxAQ raised $450 million, while media-focused Runway secured $308 million.

March: The month of mega-rounds

This was arguably the wildest month of 2025.

OpenAI closed a jaw-dropping $40 billion round, valuing the company at $300 billion.

Nexthop AI, Insilico Medicine, Celestial AI, Lila Sciences, Reflection.AI, Turing, Shield AI, and Anthropic all added nine-figure raises.

Anthropic alone secured $3.5 billion in early March.

February: Hardware and legal-tech dominate

Together AI, Lambda, Abridge, Eudia, EnCharge AI, and Harvey all raised between $100 million and $480 million.

January: A high-energy start

Synthetic voice company ElevenLabs opened the year with $180 million, followed by Hippocratic AI with a $141 million raise.